Had my first colonoscopy 4 months ago, after going for a couple of years with every red flag symptom under the sun.

The procedure was a piece of cake. As the standard is where I'm from (Norway), I was only administered some sedatives - but honestly I couldn't feel much difference. I watched the procedure on the screen, which was quite fascinating.

The worst part, by far, was the emptying / prepping. A month prior to the colonoscopy I took a stool sample (negative for blood), but my doc wanted to be safe.

In the end they nothing was found, not even polyps.

EDIT: I had put of going to it for the longest time, but a friend of mine (35 years old) was diagnosed with stage 4 last year, which pushed me to get it checked out. He had experienced prolonged constipation, that's it. When the tumor was found, the cancer had spread to both of his lungs and liver. He's still alive, and fighting it.

Had my first colonoscopy at 46. Found cancer, stage 2b. Resection and chemo. I was completely asymptomatic. I put a post on FB and I now know about a dozen people who that prompted to get their colonoscopy done. Get it done, the prep isn't bad, get the pills if you can, otherwise make sure you get a Zofran along with the prep. If found early, it's easy to treat. Get It Done.

> “Hey! CRC is going up! You should get screened!”

Try asking a doctor for asymptomatic screening (for anything), they usually say "There's a schedule for such screenings at age X, you're too young for that. There's also proven negative effects of excessive screenings."

Which kinda makes sense, as they supposed to have protocols/schedules for all kinds of healthcare. We're talking here about changing that protocols/schedules. But doctors (and insurances) are generally reluctant.

So my actionable question is "How do I convince my doctor to get the screening?"

> Yes, if you are currently young, you face higher CRC risk than previous generations did when they were young. That’s the bad news.

Unlike the usual Bettridge's law, the answer to the headline is only a qualified "No".

It is a "So is all other cancers!", which is pretty bad news for folks who are young and healthy right now.

Seeing young adults around me going through this made me change my dietary habits 1 year ago. I went to the extreme by modern food industry standards, but now:

- I take 100g proteins, 30g fibers daily

- Red meat once a week but never fried

- Most of the protein comes from eggs, yoggurt, chicken and various plant based sources

- No white bread

- No added sugars, no deserts except fruits

- Nothing fried

- No added salt

- No canned food

- Saturated fats kept at minimum.

- No spicy food

- No alcohol

The results are incredible. I lost 8 kg, my blood samples are perfect, my pulse dropped with 10, I sleep better, no migraines (I had those for years). Also this year I was the only one in the family that didn't got any cold, and that's quite hard with two kids going to kindergarten.

It's hard in the first two weeks, but afterwards it's becoming your daily routine. I also use an app to track various stats. The gameification of the diet also helped me a little.

I urge you to try this. To make it more manageable start small. For example avoid fast food for 2 weeks. Don't put any mayonnaise in your food for 1month. Stop eating white bread. And then add more and more restrictions. The hardest fight is the urge to eat sugar and drink alcohol, give it time.

People should be reminded that colonoscopy is not just a screening, it is also preventative. They often find growths that may develop into cancer, and remove them during the procedure.

Nice to have a good data-based take on this question make it to the front of HN!

One of our better microscopes these days is DNA sequencing, especially for cancer, and the particular base mutations and the sequences in which they occur give heavy clues about the types of mutagens that are going on. The DNA damage from UV radiation from the sun and bulky adduct repair from smoking damage are vastly different. Even when cells have a defect in a repair mechanism, you can tell which repair mechanism is broken based on the particular base changes in which context.

A study from 2025 reapplied these Alexandronv signatures to colorectal cancer with a global set of cohorts, and suggests that colibactin, a mutagen produced by some strains of E. coli and related bacteria, could be driving some of the increase in early age colorectal cancer:

https://www.nature.com/articles/s41586-025-09025-8

Of course we don't know exactly how much of the increase, or the other explanations; causality is multi-causal and I bring this particular cause up because it's one of the stronger leads so far. But when we've lost our keys in the night, even if its easiest to look under the light of the streetlamp, that doesn't mean its the only place we might find them.

> We don’t yet know if colonoscopies are better than other methods of screening

My Gastroentrologist told me just recently that the stool test (Cologuard) is very accurate but must be repeated every 3 years as opposed to getting a Colonoscopy which should be repeated every 7 to 10 years

I recommend getting a colonoscopy if you have any symptoms. There is a lot of stigma that prevents people from being proactive about this type of issue.

My anecdote (M, 35) is that I got one after experiencing symptoms that turned out to be unrelated, but they did find pre-cancerous polyps so now I will be getting them more regularly. I received received meaningful early detection and peace of mind. Also aside from the prep, its a very convenient procedure. You get put under anesthesia and do a quick time travel.

All this talk about different groupings (and overlapping kinds of time) makes me think of Simpson's Paradox [0], where how we slice things can be very important to what trend we see.

[0] https://en.wikipedia.org/wiki/Simpson%27s_paradox

Also increased, or we're now aware of, higher rates in long distance runners.

what is rate per 100.000 tracking? I guess it means among living persons at every datapoint. If so decreasing mortality overall and final diagnosis specifically plays a large role in the numbers

Personally I am hesitant to do colonoscopy after a relative had a botched procedure. Just this month two celebrities revealed botched colonoscopies. I hope they figure out ways to make this procedure safer.

https://www.yahoo.com/entertainment/celebrity/articles/kathy...

https://www.usatoday.com/story/entertainment/celebrities/202...

FYI there are other options besides a full scope for screening now, especially if you are low risk

Is "medical term" used "appropriately"?

Yes. Nothing to see here. And stop abusing quotation marks.

Get it done!

But not at Kaiser.

$17k later…

Maybe they're all running too many marathons.

Why are the "critical terms" in "that headline" in quotes?

Then some clown downvotes this straightforward question. Brilliant.

Very good visualization repair. I particularly appreciate the TL;DR at the end. In a world of mostly bad popular medical advice this seems competent and at least facially correct.

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I guess cancer is the new climate denial

Did you miss the BILLIONS in lawsuits against RoundUp and other herbicides?

Did you miss all the deregulation by the first and now second Trump administration allowing crazy levels of pollution and toxicity among all the industries?

They are still using leaded fuel in prop aircraft at hundreds of airports around the country and world, spraying it on unknowning population

Our environment has never been more dangerous yet people never more ignorant or carefree

Human biology is such a horror...I've been through it with enough loved ones that I've been left with two obsessions: a) a dignified way to go when my time comes, and b) we should either fix human biology, go post-biological, or simply surrender as a species and be replaced by AI. I know there are many counter-arguments to the above, but I've come to suspect the integrity of our species' rationality under the savage ravaging of Dog.