I'm in my 40s with genetic predisposition for Alzheimer's. Been seriously considering the past year or two paying out of pocket for Shingrix. I think it would be ~$500 total for two doses.

Sure, I could wait 7 or 8 years until I qualify via insurance, but is that really worth the risk for what is an easily absorbed cost to me? Especially when I have a friend in her late 30s who just went through a very rough bout of shingles?

It makes sense to have targets like age 50 for population-wide public health recommendations. But it can and does infect people of much earlier ages.

Recent articles like this make me think I'll go ahead.

So if you had shingles in your youth then you are better protected against dementia?

Replicated association, which is strong, but not proof. Initial study saw a 3.5% absolute reduction in dementia diagnoses over seven years with a very wide confidence interval. In Australia the study was replicated with 1.8% absolute reduction over 7.4 yrs. Canadian replication: 2% over 5.5 yrs.

Infections generally increase the risk of future dementia. Like the more colds you have throughout life.

Recently, even the TDAP (Tetanus) vaccine was correlated with lower incidence of dementia https://news.ycombinator.com/item?id=26919881

I recall seeing a few discussions on HN comments hypothesizing that immune system stimulation via the vaccine might be the root cause. Now that the Amyloid hypothesis is on the wane, hopefully we'll explore other paths.

I know quite a few people who got shingles in their early 20s. One of their doctors didn’t believe she had shingles until the blisters formed. The vaccine can definitely help those younger than 50, dementia benefits or not. Some of them have permanent nerve damage after getting shingles.

TL;DR Shingles vaccines reduces chances of dementia by 20%. Yet, most countries health systems only look at the upfront cost of ~$300 and don’t recommend for all who could benefit.

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Most people, especially those under the vaccination age of 50, with a weak immune system don't supplement a correct dose of basic immune boosting supplements like vitamin D3 (4-6 KIU), zinc (15-25 mg), selenium (200 mcg), and beta glucan, which typically is why they have a weak immune system in the first place. Of course the big medicine industry doesn't want you to look after yourself, and would much rather prefer you rather die with a million dollars billed to your insurance.