Found: A protein that drives ageing without unleashing inflammation
97 points - yesterday at 7:25 PM
SourceComments
neom yesterday at 8:39 PM
Paper: https://www.cell.com/immunity/fulltext/S1074-7613(26)00440-1
Granzyme K is the protein.
ethanj8011 yesterday at 10:49 PM
From the abstract of the paper, significantly more nuance.
> Despite persistent immune aging phenotypes, GzmK deficiency markedly attenuated organ aging, effectively uncoupling immune and tissue aging... These findings identify GzmK as a tissue-specific driver of organismal aging but not immune aging or systemic inflammaging.
RobotToaster yesterday at 9:23 PM
Paywall
StilesCrisis yesterday at 9:18 PM
Thank God! Finally, mice that don't age!
agnosticmantis yesterday at 8:14 PM
In mice.